A motorcycle rider has been seriously injured following a crash with a truck in Windsor on Sunday. 

About 3.40pm yesterday emergency services responded to reports of a crash between a motorcycle and truck at the intersection of Hawkesbury Valley Way and Cox Street, Windsor. 

NSW Ambulance paramedics treated the rider, an 18-year-old man at the scene before he was taken to Westmead Hospital in a serious but stable condition. 

The 45-year-old truck driver was uninjured and has been taken to Hawkesbury Hospital for mandatory testing. 

Officers from Hawkesbury Police Area Command have established a crime scene are awaiting the arrival of specialist police.

The area is expected to remain a crime scene for a considerable amount of time and drivers are urged to avoid the area.

As investigations into the incident continue anyone with information about the crash is asked to contact Windsor Police Station or Crime Stoppers on 1800 333 000.